Colchicine-Induced Hepatotoxicity

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Colchicine-Induced Hepatotoxicity

Drug-induced injury (DILI) is a frequent cause of abnormal liver tests and a leading cause of liver failure in the United States. Colchicine has long been used as a systemic anti-inflammatory agent for treatment of gout by inhibiting mitotic activity and neutrophil function. We present the first case of colchicine-induced hepatoxicity, supported by histopathologic findings characteristic of col...

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A case of colchicine-induced rhabdomyolysis is reported. The 72-year-old man was hospitalized because of poor appetite, fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine for 5 months. Laboratory results revealed serum creatine kinase: 3627 IU/L, creatinine: 2.3 mg/dL, myoglobin: 1160.5 ng/mL (reference range: male: 17.4-105.7 ng/mL, female: 14.3-65.8 ng/mL) an...

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Corresponding author: Nicola Lucio Liberato MD Internal Medicine Ospedale C. Mira Piazzale Volontari del Sangue 27022 Casorate Primo (PV), Italy Phone: +390290040224 Fax: +390290040304 E-mail: lucio_liberato@ ospedali.pavia.it 1 Internal Medicine, Azienda Ospedaliera della Provincia di Pavia, Ospedale Civile “Asilo Vittoria”, Mortara (PV), Italy 2 Internal Medicine, Azienda Ospedaliera della Pr...

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ژورنال

عنوان ژورنال: ACG Case Reports Journal

سال: 2017

ISSN: 2326-3253

DOI: 10.14309/crj.2017.120